Ridker PM, Devalarajan M, Baeres FMM, Engelmann MDMM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj DS, Libby P, Davidson M on behalf of the RESCUE Investigators. Effects of Interleukin-6 Inhibition with Ziltivekimab on Biomarkers of Inflammation Among Patients at High Risk for Atherosclerotic Events: A Randomized, Placebo Controlled Trial. Lancet. 29;397(10289):2060-2069, 2021
Wang AA, Cai X, Srivastava A, Prasad PV, Sprague SM, Carr J, Wolf M, Ix, Block JA, Chonchol, Raphael KL Cheung AK, Raj DS, Gassman J, Rahsepar AA, Middleton JP, Fried LF, Sarnari R, Isakova T, Mehta R, and the COMBINE Study Group. Abnormalities in Cardiac Structure and Function among Individuals with CKD: The COMBINE Trial. Kidney 360.
Rohrscheib M, Sam R, Raj DS, Argyropoulos CP, Unruh ML, Lew SQ, Ing TS, Levin NW, Tzamaloukas AH. Edelman Revisited: Concepts, Achievements, and Challenges. Frontiers in Medicine, 2022 Jan 10;8:808765. PMID: 35083255
Systolic Blood Pressure Intervention Trial (SPRINT) Study
Upadhya B, Willard JJ, Lovato LC, Rocco MV, Lewis CE, Oparil S, Cushman WC, Bello NA, Aurigemma G; Johnson KC, Rodriguez CJ; Raj DS, Rastogi A, Tamariz L, Wiggers A, Kitzman DW, the SPRINT Research Group. Incidence and Outcomes of Acute Heart Failure with Preserved versus Reduced Ejection Fraction in SPRINT. Circulation HF. 2021 Dec;14(12):e008322
Drawz, P. E., Rai NK, Lenoir KM, Suarez M, Powell J, Raj DS, Beddhu S, Agarwal AK, Soman S, Whelton PK, Lash JP, Rahbari-Oskoui FF, Dobre M, Parkulo MA, Rocco MV, McWilliams A, Dwyer JP, Thomas G, Rahman M, Oparil S, Horwitz E, Pajewski NM, Ishani A. Effect of Intensive vs Standard Blood Pressure Control on Acute Kidney Injury and Subsequent Cardiovascular Outcomes and Mortality: Findings from the SPRINT EHR Study. Kidney360: 2022
Drawz PE, Agarwal A, Dwyer JP, Horwitz E, Lash J, Lenoir K, McWilliams A, Oparil S, Rahbari-Oskoui F, Rahman M, Parkulo MA, Pemu P, Raj DS, Rocco M, Soman S, Thomas G, Tuot DS, Whelton PK, Pajewski NM. Concordance Between Blood Pressure in the Systolic Blood Pressure Intervention Trial and in Routine Clinical Practice. JAMA Intern Med. 2020 Dec 1;180(12):1655-1663. PMID: 33044494
Beddhu S, Boucher RE, Sun J, Balu N, Chonchol M, Navaneethan S, Chertow GM, Townsend R, Haley W, Cheung AK, Conroy MB, Raj DS, Xu D, George T, Yunis R, Wei G, Canton G, Bates J, Chen J, Papademetriou V, Punzi H, Wiggers A, Wright JT, Greene T, Yuan C. Chronic kidney disease, atherosclerotic plaque characteristics on carotid magnetic resonance imaging, and cardiovascular outcomes. BMC Nephrol. 24;22(1):69, 2021
Upadhya B, Rocco MV, Pajewski NM, Morgan T, Blackshear J, Hundley WG, Oparil S, Soliman EZ, Cohen DL, Hamilton CA, Cho ME, Kostis WJ, Papademetriou V, Rodriguez CJ, Raj DS, Townsend R, Vasu S, Zamanian S, Kitzman DW; SPRINT Research Group *. Effect of Intensive Blood Pressure Reduction on Left Ventricular Mass, Structure, Function, and Fibrosis in the SPRINT-HEART Hypertension. 2019 PMID: 31256724
Upadhya B, Rocco M, Lewis CE, Oparil S, Lovato LC, Cushman WC, Bates JT, Bello NA, Aurigemma G, Fine LJ, Johnson KC, Rodriguez CJ, Raj DS, Rastogi A, Tamariz L, Wiggers A, Kitzman DW; SPRINT Research Group. Effect of Intensive Blood Pressure Treatment on Heart Failure Events in the Systolic Blood Pressure Reduction Intervention Trial. Circ Heart Fail. 2017 Apr;10(4) PMID: 28364091
Sprint Research Group. A randomized trial of intensive versus standard blood pressure control. New Engl J Med 2015 26, 2103-2116
Freedman BI, Gadegbeku CA, Bryan RN, Palmer ND, Hicks PJ, Ma L, Rocco MV, Smith SC, Xu J, Whitlow CT, Wagner BC, Langefeld CD, Hawfield AT, Bates JT, Lerner AJ, Raj DS, Sadaghiani MS, Toto RD, Wright JT, Jr., Bowden DW, Williamson JD, Sink KM, Maldjian JA, Pajewski NM, Divers J: APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume. Kidney Int 90:440-449, 2016
Langefeld CD, Divers J, Pajewski NM, Hawfield AT, Reboussin DM, Bild DE, Kaysen GA, Kimmel PL, Raj DS, Ricardo AC, Wright WT, Sedor JR, Rocco MV, Freedman BI. Association between apolipoprotein L1 gene variants with prevalent kidney and cardiovascular disease: Systolic Blood Pressure Intervention Trial, Kidney Int, 87, 169-175, 2015
Chronic Renal Insufficiency Cohort (CRIC) study
Barrows IR, Devalaraja M; Kakkar R, Chen J, Gupta J, Rosas SE, Saraf S, He J, Go A, Raj DS, Amdur RL. Race, Interleukin-6, TMPRSS6 Genotype and Cardiovascular Disease in Patients with Chronic Kidney Disease. J Am Heart Assoc. (In press)
Chen Y, Zelnick LR, Huber MP, Wang K, Bansal N, Hoofnagle AN, Paranji RK, Heckbert SR, Weiss NS, Go AS, Hsu CY, Feldman HI, Waikar SS, Mehta RC, Srivastava A, Seliger SL, Lash JP, Porter AC, Raj DS, Kestenbaum BR; CRIC Study Investigators. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 78(2):226-235, 2021
Kalim S, Berg AH, Karumanchi SA, Thadhani R, Allegretti AS, Nigwekar S, Zhao S, Srivastava A, Raj DS, Deo R, Frydrych A, Chen J, Sondheimer J, Shafi T, Weir M, Lash JP; CRIC Study Investigators. Protein carbamylation and chronic kidney disease progression in the Chronic Renal Insufficiency Cohort Study. Nephrol Dial Transplant. 31;37(1):139-147, 2021
Orlandi PF, Xie D, Yang W, Cohen JB, Deo R, Ricardo AC, Schrauben S, Wang X, Hamm LL, He J, Sondheimer JH, Kallem K, Townsend R, Raj DS, Parsa A, Anderson AH, Feldman HI, and the CRIC Study Investigators* Slope of kidney function and its association with longitudinal mortality and cardiovascular disease among individuals with chronic kidney disease. J Am Soc Nephrol,31 (12) 2912-2923, 2020
Amdur RL, Feldman HI, Gupta J, Yang W, Kanetsky P, Shlipak M, Rahman M, Lash JP, Townsend RR, Ojo A, Roy-Chaudhury A, Go AS, Joffe M, He J, Balakrishnan VS, Kimmel PL, Kusek JW, Raj DS: Inflammation and Progression of CKD: The CRIC Study. Clin J Am Soc Nephrol 2016
Amdur RL, Mukherjee M, Go A; Barrows IR, Ramezani A, Shoji J, Reilly M; Gerald J,Deo R, Roas S, Keane M, Master S, Teal V, Soliman EZ, Yang P, Feldman H, Kusek JW, Tracy C, Raj DS: Interleukin-6 is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study, PLos one 1(2): e0148189, 2016
Gupta J, Dominic EA, Fink JC, Ojo AO, Barrows IR, Reilly MP, Townsend RR, Joffe MM, Rosas SE, Wolman M, Patel SS, Keane MG, Feldman HI, Kusek JW, Raj DS. Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study. PLos one, 10(4):e0124772, 2015
Wing MR, Yang W, Teal V, Navaneethan S, Tao K, Ojo A, Guzman NN, Reilly M, Wolman M, Rosas SE, Cuevas M, Fischer M, Lustigova E, Master SR, Xie D, Appleby D, Joffe M, Kusek J, Feldman HI, Raj DS: Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: Findings from the CRIC study. Obesity 22:1359-66, 2014
Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT, Jr., Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ: APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease. N Engl J Med 369(23):2183-96, 2013
Role of microRNAs in kidney disease
Sheng X, Qiu C, Liu H, Gluck C, Hsu JY, He J, Hsu C, Sha D, Weir MR, Isakova T, Raj DS, Rincon-Choles H, Feldman HI, Townsend R, Li H, Susztak K. Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease. Proc Natl Acad Sci U S A, 117 (16) 29013-29024, 2020
Latt KZ, Heymann J, Jessee JH, Rosenberg AZ, Berthier CC, Arazi A, Eddy S, Yoshida T, Zhao Y, Chen V, Nelson GW, Cam M, Kumar P, Mehta M, Kelly MC, Kretzler M, The Nephrotic Syndrome Study Network (NEPTUNE), The Accelerating Medicines Partnership in Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) consortium, Ray PE, Moxey-Mims M, Gorman GH, Lechner BL, Regunathan-Shenk R, Raj DS, Susztak K, Winkler CA, Kopp JB, Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures, Kidney Int Reports (2021), 2021
Muralidharan J, Ramezani A, Hubal MJ, Knoblach S, Shrivastav S, Karandish S, Scott R, Maxwell N, Ozturk S, Beddhu S, Kopp JB, Raj DS: Extracellular microRNA signature in chronic kidney disease. Am J Physiol Renal Physiol, 312, F982-F991, 2017
Nassirpour R, Raj DS, Townsend R, Argyropoulos C. MicroRNA biomarkers in clinical renal disease: Diabetic nephropathy and renal transplantation to chronic kidney disease and beyond. Food and Chemical Toxicology 2016 Dec;98(Pt A):73-88. 2016
Ramezani R, Massy ZA, Meijers B, Evenepoel P, Vanholder R, Raj DS. The Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target - A potential therapeutic target. Am J Kidney Dis 2016 Mar;67(3):483-98. 2015
Gut Microbiome
Shankarnarayanan D, Raj DS, Gut microbiome and kidney disease: Reconciling Optimism and Skepticism. C-JASN (In press)
Shi X, Gao G, Srivastava A, Izzi Z, Abdalla A, Shen W, Raj DS. Alterations of gut microbial pathways and virulence factors in hemodialysis patients. Frontiers Cellular and Infection Microbiology (In press)
Armani, R. G., Carvalho AB, Ramos CI, Hong V, Bortolotto LA, Cassiolato JL, Oliveira NF, Cieslarova Z, do Lago CL, Klassen A, Cuppari L, Raj DS and Canziani MEF. Effect of fructooligosaccharide on endothelial function in CKD patients: a randomized controlled trial. Nephrology Dialysis Transplantation. 37, 85-91, 2021
Shah NB, Allegretti AS, Nigwekar SU, Kalim S, Zhao S, Lelouvier B, Servant F, Serena G, Thadhani RI, Raj DS, Fasano A. Blood Microbiome Profile in CKD: A Pilot Study. Clin J Am Soc Nephrol. 2019 PMID: 30962186
Ramezani A, Nolin TD, Barrows IR, Serrano MG, Buck GA, Regunathan-Shenk R, West RE 3rd, Latham PS, Amdur R, Raj DS. Gut Colonization with Methanogenic Archaea Lowers Plasma Trimethylamine N-oxide Concentrations in Apolipoprotein e-/- Mice. Sci Rep. 2018 PMID: 30283097
Pilot studies in CKD Consortium
Wang AA, Cai X, Srivastava A, Prasad PV, Sprague SM, Carr J, Wolf M, Ix, Block JA, Chonchol, Raphael KL Cheung AK, Raj DS, Gassman J, Rahsepar AA, Middleton JP, Fried LF, Sarnari R, Isakova T, Mehta R, and the COMBINE Study Group. Abnormalities in Cardiac Structure and Function among Individuals with CKD: The COMBINE Trial. Kidney 360, 2021.
Raphael KL, Isakova T, Ix JH, Raj DS, Wolf M, Fried LF, Gassman JJ, Kendrick C, Larive B, Flessner MF, Mendley SR, Hostetter TH, Block GA, Li P, Middleton JP, Sprague SM, Wesson DE, Cheung AK. A randomized trial comparing the safety, adherence, and pharmacodynamics profile of two doses of sodium bicarbonate in CKD: The BASE Pilot Trial. J Am Soc Nephrol, 21,161-174, 2020
Srivastava A, Cai X. Lee J, Li W, Larive B, Kendrick C, Gassman JJ, Middleton JP, Carr J, Raphael, KL, Cheung AK, Raj DS, Chonchol MB, Fried, LF, Block GA, Sprague SM, Wolf M, Ix JH., Prasad PV, Isakova T. Kidney Functional Magnetic Resonance Imaging and Change in eGFR in Individuals with CKD. CJASN, 15(6), 776–783. 2020
Ix JH, Isakova T, Larive B, Raphael KL, Raj DS, Cheung AK, Sprague SM, Fried L, Gassman JJ, Middleton J, Flessner M, Block G, Wolf M. Effects of Nicotinamide and Lanthanum Carbonate on Serum Phosphate and Fibroblast Growth Factor-23 in Chronic Kidney Disease: The COMBINE Trial. J Am Soc Nephrol 30(6):1096-1108.2019
Hemodialysis Novel Therapies Consortium
Raj DS, Sohn MB, Charytan DM, Himmelfarb J, Ikizler TA, Mehrotra R, Ramezani A, Regunathan-Shenk R, Hsu JY, Landis JR, Li H, Kimmel PL, Kliger AS, Dember LM for Hemodialysis Novel Therapies Consortium. The Microbiome and p-Inulin in Hemodialysis: A Feasibility Study. Kidney 360. 2 (3) 445-455, 2021
